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October 14, 1893

THE ACTION AND SAFETY OF CHLOROFORM.Being an abstract of a report to Surgeon Lieutenant Colonel Edward Lawrie and the Government of His Highness, the Nizam of Hyderabad, India.

JAMA. 1893;XXI(16):573-577. doi:10.1001/jama.1893.02420680023002f

To any one who endeavors to view the subject of chloroform anesthesia in an entirely impartial light, two objects raise themselves so high above all others that they form the peaks about which the smaller questions must cluster. The first object on which the judicial eye rests is the firm belief of many clinicians that chloroform may cause sudden cardiac death; the second object to be seen is the statement of the Hyderabad Chloroform Commissions that death from chloroform is never due to cardiac failure. In the support of the first belief we have not only wide clinical observation but also the experimental evidences of a number of investigations. In support of the second statement we have an array of experimental study, not equaled by any other research extant, associated with an enormous number of negative observations on man. Negative observations, because Lawrie alone in 25,000 cases has never had