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May 26, 1917


JAMA. 1917;LXVIII(21):1531-1533. doi:10.1001/jama.1917.04270050233004

The question of the production of a horse serum that will have protective and curative properties against the virus of poliomyelitis has occupied the attention of many investigators. So far as we can discover no one has reported the discovery of a horse serum that will either neutralize the virus in vitro or protect an animal against the virus of poliomyelitis. Flexner,1 who was the first to attempt to produce an immune horse serum, reports:

It has, for instance, been found that the horse does not readily respond even to large injections of filtrates carrying the active virus with the development of immunity principles within the blood. It is true that our experiments are restricted for the present to a single horse, the blood serum of which, after many months of treatment, had no restraining effect on the virus either in vitro or within the body.

From all the experimental

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