In the experience of European observers, disseminating multiple sclerosis is considered one of the most common organic diseases of the central nervous system, but is spoken of by American writers as of unusual occurrence, Church referring to it as uncommon. There is no evident reason why it should not occur as frequently in this country as abroad, and the only explanation for its infrequent recognition with us must be that many cases are at present overlooked; and if we are to withhold a positive diagnosis until the so-called classical syndrome of Charcot is presented in its entirety, or even a very close approach to this picture, a great majority of all cases of this exceedingly interesting and widely variant congeries will continue to pass unrecognized, for there is but a comparatively small proportion of all cases that present this grouping.
Close analysis of the commonly attributed etiologic factors, when applied
CRAFTS LM. THE EARLY RECOGNITION OF MULTIPLE SCLEROSISWITH REPORT OF THIRTEEN CASES. JAMA. 1917;LXIX(14):1130–1137. doi:10.1001/jama.1917.02590410008003
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