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Article
June 2, 1917

TWO CASES OF PERFORATION OF THE NASAL SEPTUM DUE TO THE INHALATION OF ARSENIC TRIOXID

JAMA. 1917;LXVIII(22):1620-1621. doi:10.1001/jama.1917.04270060028011
Abstract

Recently I was consulted by a man, married, aged 35, who said that for the past four or five weeks he had been troubled with stuffiness in his nose and a slight nasal discharge; that for the past two or three weeks he had occasionally noticed a little blood on his handkerchief after blowing his nose, and that for the past week, while applying an ointment to the mucous membrane of his nose with a piece of cotton, he had been able to pass the cotton from one nostril to the other through the septum. He desired confirmation of his diagnosis of a perforation of the septum.

Examination disclosed a hole through the cartilaginous septum, about 1 cm. in diameter, not involving the bony septum. The edges of the hole were everted, hyperemic and edematous, while the raw surfaces presented a blackened worm-eaten appearance. There were no granulations suggestive of

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