If the earliest symptoms and signs of consumption were as easily definable and as pathognomonic of the disease as those manifested in the later stages, it might be easily diagnosed in its incipiency. But, unfortunately, this has not been the fact. In a great many cases the onset is sudden or occurs during the progress of a severe cold or bronchial catarrh, or following in the wake of some other acute disease. Frequently, however, it is ushered in by symptoms which point to no particular form of disease, and it is this class of cases that is the most puzzling until we find pronounced symptoms pointing to lung infection. There are often certain symptoms of a general constitutional impairment, insufficient in themselves to render a diagnosis possible, but which do point to a definite disease if properly studied. There are many cases occurring in active practice in which a positive
WEAVER WH. TUBERCULIN IN OBSCURE MANIFESTATIONS OF TUBERCULOSIS. JAMA. 1897;XXVIII(3):109–110. doi:10.1001/jama.1897.02440030013001i
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