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December 2, 1893

THE TREATMENT OF DIPHTHERIA.Read in the Section on Diseases of Children at the Forty-fourth Annual Meeting of the American Medical Association.

JAMA. 1893;XXI(23):848-849. doi:10.1001/jama.1893.02420750018002d

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It is to be hoped that in the not far distant future the inoculation treatment of diphtheria will supersede or largely displace all other treatments. The researches in the field of bacteriology; the discovery of the Klebs-Löffler bacillus and the various experiments with ptomaines and anti-toxines are most assuring. Yet notwithstanding the fact that Bering and Kitasato have clearly demonstrated that cultures, which will invariably kill susceptible animals in very small amounts, have their toxic properties entirely destroyed by the addition of the blood of an immune animal; and while the experiments upon animals have been such as to give us confidence in the future treatment of the disease by inoculation, yet for the present we must rely upon the well-tried methods of to-day.

While mice inoculated with a virulent filtrate, neutralized by the addition of immune blood have remained immune to diphtheria for forty or fifty days, yet this

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