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Article
November 3, 1917

INSOLUBILITY OF SOFT GELATIN CAPSULESEXPERIMENTS SHOWING THAT SOFT CAPSULES ARE RELATIVELY INSOLUBLE IN THE STOMACH

JAMA. 1917;LXIX(18):1508-1509. doi:10.1001/jama.1917.02590450028009
Abstract

At all times, and at the present time especially, it is of great importance to both physician and patient that all drugs be administered in a form that is easily digested and absorbed. Sometimes, however, in our efforts to make medicines pleasing to the palate of our patients, we may succeed too well, with the result that the coatings protect the drugs not only from the action of the saliva, but from the gastric and enteric juices as well. Recent experiments seem to prove that soft gelatin capsules do this very thing.

In September of last year, a local firm offered us some thymol at a very attractive price, stating that they were able to quote so low a price because the thymol had been ordered before the war. Examination of the samples showed that for some reason the drug had been put into soft capsules. To test their solubility

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