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July 11, 1885


JAMA. 1885;V(2):50-51. doi:10.1001/jama.1885.04470010022011

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(FROM OUR OWN CORRESPONDENT.)  Pyridine—Its Chemical History—Method of Administration—Soporific Effects—Its Value in Asthma.Pyridine is the name given to a new substance introduced by Prof. Germain Sée in the treatment of asthma. Wishing to ascertain the rationale of the treatment of asthma by the smoking of medicated cigarettes and the veritable physiological agent to which the cure is attributable, Prof. Sée, in conjunction with Dr. Bochefontaine, discovered by chemical analysis that the therapeutic action of the cigarettes was due to a uniform base formed by the combustion of certain plants and of certain alkaloids. This substance is pyridine, which is developed during the distillation of dry organic matters in the products of bony tissues (animal oil of Dippel), coal-tar, and certain important alkaloids, such as cinchonine, quinine and morphine; it is also found in the products condensed from the fumes of tobacco, and, finally, it is found in nicotine itself,

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