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September 28, 1907


JAMA. 1907;XLIX(13):1119-1120. doi:10.1001/jama.1907.02530130053005

The phenomenon of a local reaction in the subject of an infectious disease on the injection of the corresponding toxin, and its application by von Pirquet in eliciting a cutaneous reaction in tuberculosis were commented on some weeks ago.1 A distinct advance in the method of utilization of this principle in diagnosis was made when Calmette2 showed that if tuberculin were instilled into the eye there would be a marked congestive reaction in the case of tuberculous patients, while the healthy or non-tuberculous responded with a very much milder reaction. Calmette makes use of a. 1 per cent, aqueous solution of the precipitate obtained on the addition of alcohol to tuberculin. Within three or four hours after the instillation of one drop of this solution a marked congestion of the palpebral conjunctiva is noted in the tuberculous subject. The caruncle becomes swollen, red and covered with a light

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