I. The Preparation of the Reagent
J. H. BLACK, M.D., AND LOUIS ROSENBERG, M.D.To one who has even a casual acquaintance with the literature of colloidal gold solutions, three things are at once apparent: 1. There is a general agreement that satisfactory solutions are difficult of preparation. 2. There are approximately as many variations in technic as there are workers. 3. There is unanimity of opinion that the use of the solution in the diagnosis of diseases of the central nervous system has a very definite value.The major portion of the work done in this country has been carried on with a more or less close adherence to the technic of Lange,1 variations being introduced by the individual worker in the effort to produce uniform results. It is quite true that many men have been able to produce satisfactory solutions -some of them with considerable regularity —
BLACK JH, ROSENBERG L, McBRIDE RB. THE COLLOIDAL GOLD TEST: THE PREPARATION OF THE COLLOIDAL GOLD SOLUTION AND ITS APPLICATION TO DISEASES OF THE CENTRAL NERVOUS SYSTEM. JAMA. 1917;LXIX(22):1855–1859. doi:10.1001/jama.1917.02590490019003
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