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December 8, 1917


JAMA. 1917;LXIX(23):1972. doi:10.1001/jama.1917.02590500054017

The influence exerted by the genital glands on the other parts of the reproductive apparatus, and on the body generally, is a remarkable illustration of the chemical correlations that may exist in the organism. That the lack of the sex glands—a situation which arises as the result of castration—may bring about conspicuous alterations in physique and modifications of the expected development is a fact long familiar. When the removal of testes or ovaries is carried out early enough, that is, before the period of puberty, the development of the so-called secondary sexual characters is interfered with. We must regard the germ cells, says Starling, not only as representing the cells from which the individuals of the new generation may be developed, but also as concerned in the formation of chemical substances which, discharged into their hosts, affect many or all of the functions of the latter, with the object of

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