Experimental and clinical observations have taught us that oils when they cannot be swallowed, or are rejected by the stomach, can be absorbed by inunction and subcutaneous injection; and numerous instances of the absorption and assimilation of oil and fat by the skin have been reported, and their value in certain conditions, employed in this way, has been fully recognised. But the more rapid and effective use of these agents subcutaneously, while known, has had little or no practical application.
Menzel and Perco first demonstrated the subcutaneous absorption of fat by injecting an ounce of it, in a fluid state, under the skin of a dog, and in the course of forty-eight hours it disappeared, without leaving any local effect. The first practical application of this discovery was probably made by Krueg on an insane patient who refused to eat. Subcutaneous injections of olive oil, twice daily, were then administered,
SHOEMAKER JV. THE TREATMENT OF DISEASES BY THE HYPODERMATIC INJECTION OF OILS. JAMA. 1885;V(9):229–231. doi:10.1001/jama.1885.02391080005001a
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