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September 19, 1885


JAMA. 1885;V(12):325-326. doi:10.1001/jama.1885.02391110017004

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Our knowledge of the action of diuretics has within a comparatively recent period received very important contributions, chiefly through anatomical and physiological sources, so that now the physiology of the renal function may be looked upon as fairly well settled. While to the researches of Bowman we are largely indebted for directing investigation into the correct channel, as to the anatomical sources of the urinary secretion, yet it was reserved for Heidenhein actually to prove what Bowman had foreshadowed, that the urine consists of a compound product whose elements are derived from two sources: the aqueous for the most part from the vessels composing the glomeruler tuft, while the solids are the product of the epithelial cells of the convoluted tubes. This at once led to a more rational and thorough understanding, not only of the physiology of the renal function and of the morbid conditions most commonly interfering therewith,

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