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October 3, 1885

ASPIRATION A CAUSE OF THE SPREAD OF TUBERCULOSIS WITHIN THE LUNGS.

JAMA. 1885;V(14):379-381. doi:10.1001/jama.1885.02391130015004

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Abstract

In the Zeitschrift für Klinische Medicin, vol. 3, Professor Leyden, of Berlin, publishes an article entitled " Klinisches über den Tuberkel-Bacillus," wherein he announces very decidedly his belief in the possibility of auto-infection in tuberculosis. He states that the extension of tuberculosis within the lungs takes place in the later stages of the disease, when, owing to the weakened state of the organism, the ability to expectorate becomes inadequate to expel the offending secretion: The ineffectual efforts, that are made to cough, only result in dislodging the stagnant material, which, during each act of forced inspiration, is driven by a process of aspiration into more distant parts. The alveoli, thus invaded by a substance rich in bacilli, furnish a fresh starting-point for the disease. This proposition, which is not new, is yet worthy of thoughtful consideration. It will be observed that Leyden limits this occurrence to the later stages of consumption;

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