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M. Pierre Apéry, of Constantinople, calls attention, in Les Nouveaux Remèdes, of November 1, 1885, to the presence of uroglaucine (indigo blue) in the urine of scarlet fever patients. In a series of twelve analyses of urine from as many cases of scarlet fever, he found in every case a greater or less quantity of this substance deposited in small blue masses, which are so distinctive that they can scarcely be confounded with any other substance. Neubauer, Vogel, Kletzinsky and Schunck state that uroglaucine and urrhodine (indigo red) are sometimes found in the sediment of urine in cases of cystitis and Bright's disease, but rarely in the urine itself. But, so far as we are aware, Apéry is the first to announce the presence of the former in the urine of scarlet fever.
Uroglaucine may be recognized by filtering the urine and the deposits. The filtrate is then dried, and
UROGLAUCINE IN THE URINE IN SCARLATINA. JAMA. 1885;V(21):577–578. doi:10.1001/jama.1885.02391200017005
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