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To the Editor of the Journal:
—As a contribution to the aggregate of experience from which the value and application of cocaine is to be determined, I am able to give your readers a statement of its action upon myself while submitting to the removal of a lipoma. The tumor was situated on the nape of the neck, and with the outlying integument formed a body about the size of a closed fist. Thirty minims of water containing in solution gr. j 1/3 of cocaine hydrochlorate were injected at six points over and about the circumference of the growth. In addition to this, a mixture of ice and salt was applied for about two minutes after the injection of the cocaine. In about the same time the integument exhibited signs of freezing, whereupon the refrigerant was removed and an incision about five inches long was painlessly made.Dr.
Markham HC. COCAINE IN SURGERY—PERSONAL EXPERIENCE OF ITS EFFECTS. JAMA. 1885;V(21):586. doi:10.1001/jama.1885.02391200026011
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