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During the past ten years that I have been engaged in the practice of ophthalmic medicine and surgery, I have had the opportunity of seeing a considerable number of cases of exophthalmic goitre. The pathogeny and treatment of this remarkable disease are very unsettled and therefore very unsatisfactory. With a view of adding something to my limited knowledge of this subject beyond what I was able to gather from its literature, I adopted, in the beginning, the practice of keeping somewhat extended notes of every case of the disease that came under my observation. I have selected five typical cases for the subject of this paper, and herewith present the results of my observations to the readers of the Journal.
Palpitation of the heart, enlargement of the thyroid gland, and prominence of the eyeballs formed a marked trio of symptoms which were present in all five of the cases selected.
THOMPSON JW. EXOPHTHALMIC GOITRE, OR GRAVES' DISEASE. JAMA. 1885;V(22):597–598. doi:10.1001/jama.1885.02391210009002a
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