Weber's syndrome means, clinically, a complete or partial paralysis of the oculomotor nerve combined with a contralateral hemiplegia. Pathologically, it signifies some lesion of one of the cerebral peduncles (the crus cerebri). The practical value of this syndrome lies in the possibility of precisely locating a brain lesion, since the presence of Weber's syndrome is a sure evidence of involvement of a portion of the brain — the peduncular region — that so far has been absolutely inaccessible to operative interference.
Weber's syndrome will be complete and pronounced when that part of the peduncle is involved which is adjacent to the oculomotor nerve, that is, the inner portion. Otherwise, the oculomotor nerve may be spared, and then, in spite of the presence of a peduncular lesion, the syndrome will be lacking and will have no value as a sign of localization. Cases of this type have been reported by Andral,
HASSIN GB. WEBER'S SYNDROME: WITH REPORT OF A CASE. JAMA. 1917;LXIX(26):2169–2170. doi:10.1001/jama.1917.02590530011005
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