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Pusey has called attention to the important part played by long standing, dry seborrhea in the production of senile keratoses and similar precancerous lesions of the skin, and Heidingsfeld has shown that cicatricial tissue frequently serves as a starting point for cutaneous carcinoma.
The fact that areas of skin that have been subjected to frostbite, and especially to repeated frostbite, are abnormally susceptible to cancerous involvement has not, however, been sufficiently emphasized. The parts commonly involved are the ears, particularly the helixes, and the cheeks. The great frequency with which these areas are attacked can be appreciated only by a study of a considerable number of case histories. Of forty-six cases of seborrheic keratosis involving the ears and cheeks, examined during the twelve months elapsing Nov. 1, 1917, twenty-seven gave a history of frostbite. Of the twenty-seven, twenty-one presented one or more malignant growths on the affected areas. The majority
SUTTON RL. FROSTBITE AS A PREDISPOSING FACTOR IN CARCINOMA OF THE EAR. JAMA. 1917;LXIX(26):2171. doi:10.1001/jama.1917.02590530013007
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