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December 29, 1917


JAMA. 1917;LXIX(26):2186-2187. doi:10.1001/jama.1917.02590530028019

The excretion of creatin in the urine is a phenomenon now generally recognized to occur at times in normal persons. The intake of a very large quantity of creatin may lead to some elimination of this compound; but creatinuria occurs in healthy persons under conditions that are not referable to such a cause. Normal men do not excrete creatin through the kidneys under usual conditions of diet. Normal children, however, are now recognized to excrete creatin commonly during the period of adolescence. This was demonstrated in this country several years ago by W. C. Rose1 at Yale University and verified by Folin and Denis2 at the Harvard Medical School. Subsequently Krause3 showed that the younger the child, the less its ability to retain creatin administered by the mouth. These observations have been puzzling to the physiologist and have led to a variety of hypotheses as to the