In discussing the subject of local therapy of syphilis of the central nervous system, it is timely to recall some of the problems which are presented in the various phases of this disease. While all the types are due to the activity of the Spirochaeta pallida, the amount and kind of treatment are largely determined by a consideration of the localization of the lesion, whether in the cortex, cord, meninges or blood vessels, by the difference in the nature of the response of the various tissues, and by the stage of the disease. The recently introduced laboratory aids in the diagnosis of syphilis of the cerebrospinal axis have allowed us to lose sight of the necessity of making these anatomic distinctions, and there has been a tendency to consider all cases the same when undertaking their treatment.
In the early stages of syphilis we have learned, by means of frequent
SWIFT HF. INTRASPINAL THERAPY IN SYPHILIS OF THE CENTRAL NERVOUS SYSTEM. JAMA. 1915;LXV(3):209–214. doi:10.1001/jama.1915.02580030001001
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