About six years ago we began to observe a condition of the pupil which seemed always to be associated with patients registering a high blood pressure. A review of the literature and a careful clinical study of a large series of patients seem to confirm our original deductions as to the clinical significance of this sign, which is herein described. Patients afflicted with fundus disease, or with any condition which might interfere in any way with the reaction of the pupil, were not included in our notations.
This pupil is found to be larger than the average normal pupil, with a usual minimum size of 4.5 mm. to 5.0 mm. in width, contracts promptly to light stimulus, but immediately returns to the original size and there remains, without the light stimulus having been changed.
While it is not claimed that this reaction is pathognomonic of arteriosclerosis with high blood pressure,
WIENER M, WOLFNER HL. A REACTION OF THE PUPIL, STRONGLY SUGGESTIVE OF ARTERIOSCLEROSIS WITH INCREASED BLOOD PRESSURE. JAMA. 1915;LXV(3):214–216. doi:10.1001/jama.1915.02580030006002
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