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Article
July 17, 1915

IMMEDIATE RESULTS OF SPLENECTOMY IN PERNICIOUS ANEMIA

Author Affiliations

BOSTON

From the West Medical Service, Massachusetts General Hospital, Dr. Richard C. Cabot, Chief of Service.

JAMA. 1915;LXV(3):216-220. doi:10.1001/jama.1915.02580030008003
Abstract

Recently splenectomy has been advocated as a therapeutic procedure in pernicious anemia. Eppinger,1 Moffitt,2 von Decastello3 and others have discussed the theoretical and experimental evidence for the assumption that the etiologic factor of pernicious anemia resides in the spleen. Isolated case reports of splenectomy in pernicious anemia have appeared in the American and English literature.

We desire to present five out of seven cases of typical pernicious anemia which were admitted to the West Medical Service during a period of approximately two months, extending from Nov. 12, 1914, to Jan. 9, 1915. Of the two cases in which operation was not performed, one patient was moribund at admission and died in three days, in spite of transfusion. The second was in very poor condition with a red count of 500,000, and died before a donor could be procured for transfusion. Thus it can be fairly said that

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