The vaccine treatment of ringworm of the scalp rests on the fundamental fact that, in the blood of children suffering from this affection, there is a specific antibody which produces a positive complement-fixation test and gives a positive skin reaction.
Dr. Kolmer and I found 78 per cent, positive fixation tests in children suffering from tinea tonsurans. This work was done with controls, not only against various dermatologic affections, but also against syphilis, all of which controls were negative. In performing this reaction, the ringworm fungus was used as the antigen. We inject 0.05 c.c. of a suspension of dead ringworm fungus in salt solution, which has been briefly centrifuged at low speed, so that it is of about the same density as luetin. When we inject it into the superficial skin layer of the arm of children suffering from tinea tonsurans, we obtain reactions in the vast majority of
STRICKLER A. THE VACCINE TREATMENT OF RINGWORM OF THE SCALP. JAMA. 1915;LXV(3):224–227. doi:10.1001/jama.1915.02580030016007
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