In an endeavor to devise a reliable and convenient test of liver function, Rowntree, Hurwitz and Bloomfield1 have suggested the use of the dye phenoltetrachlorphthalein, and have perfected a method for its administration and subsequent estimation in the feces. They report studies of this test in sixty-seven patients, thirty-seven of whom, including those with myocardial insufficiency, were classified as having pathologic livers. They state that the number of cases thus far observed is too small to warrant far-reaching deductions, but conclude that their studies "indicate that the excretion of tetrachlorphthalein will be useful in the estimation of the functional capacity of the liver."
Chesney, Marshall and Rowntree2 studied this and other tests in forty-five cases. They express the opinion that the determination of phenoltetrachlorphthalein excretion is of decided value in revealing the presence of, and to a less degree the extent of, functional liver involvement.
McLESTER JS, FRAZIER B. PHENOLTETRACHLORPHTHALEIN TEST OF LIVER FUNCTION: IN A SERIES OF UNSELECTED CASES. JAMA. 1915;LXV(5):383–387. doi:10.1001/jama.1915.02580050011004
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