The poison under discussion may be obtained from the fluid above an intestinal obstruction, from a closed washed loop of small intestine or from the mucosa of a closed loop or a loop draining externally through an enterostomy wound. The intoxication which develops with intestinal obstruction or after producing a closed or drained intestinal loop is very similar, differing only in intensity. In like manner one can inject this poison into a dog and produce more or less profound intoxication, depending on the amount of poison introduced. This intoxication resembles closely that observed following intestinal obstruction. The evidence is overwhelming that an active poison is concerned in the production of the clinical picture of intestinal obstruction and of the closed intestinal loops.
The poison is found in rather concentrated form within the lumina of the closed loops of the small intestine. Dogs can be immunized by sublethal doses and can
WHIPPLE GH. INTESTINAL OBSTRUCTION: A PROTEOSE INTOXICATION. JAMA. 1915;LXV(6):476–478. doi:10.1001/jama.1915.02580060008003
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