By malignant forms of malaria I mean those cases of malaria that prove fatal, those that would prove fatal without proper treatment and those that are sufficiently severe to immediately endanger the life of the patient. The specific treatment of this or any other form of malaria is treatment with quinin. There is no other specific remedy for malaria.
Practically all cases of malignant malaria are due to the estivo-autumnal plasmodium (P. falciparum). This parasite spends about three-fourths of its life cycle lodged in capillaries and only about one-fourth in the circulating blood. The very fact that it remains during so large a portion of its life in capillaries enables it to produce the severe forms of malaria. It seems quite possible that prevention of the proper flow of blood through the capillaries of vital organs by large numbers of plasmodia lodged in them may be the chief source of
BASS CC. SPECIFIC TREATMENT OF THE MALIGNANT FORMS OF MALARIA. JAMA. 1915;LXV(7):577–579. doi:10.1001/jama.1915.02580070011004
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