The clinical history of syphilis with its therapy is in the process of making, and is greatly in need of restating. Especially is this true of nervous syphilis. The reports of many investigators are so incomplete, so lacking in scientific accuracy, as to cloud their findings and give rise to great confusion and difference of opinion. Paucity of experience, the failure to follow lines of procedure marked out by previous well-known and competent investigators, substituting therefor personal and theoretical modifications, are all important factors in the production of this deplorable condition. There are but few Noguchis or Marinescos, few Swifts and Ellises.
There must be mutual endeavor; a cooperation of effort, so to speak, along definite lines among those interested in the therapy of syphilitic nervous diseases, if order is to come out of chaos and definite and reliable data be obtained.
Mattauschek found from the examination of 4,134 cases
RIGGS CE. SALVARSANIZED SERUM IN SYPHILITIC NERVOUS DISEASE: SOME SALIENT FACTS: THE METHOD, THE DRUG, THE RESULTS. JAMA. 1915;LXV(10):840–848. doi:10.1001/jama.1915.02580100004002
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