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In a great variety of cases, the indiscriminate and empiric use of the Bulgarian bacillus as a therapeutic agent not only causes distress, but often, also, evil results. If its use is continued it produces a condition approaching acidosis.
An acid-producing organism, when used in internal medication in conditions in which there are anemia, cachexia, and emaciation, only adds more fuel to the fire by further increasing the acidosis which has been already produced.
That acid-forming organisms multiplying in the alimentary tract tend to neutralize the normal alkaline secretion of the intestines is not questioned. When taken by patients suffering from emaciating diseases, they evidently do neutralize it altogether, as will be shown later in the cases to be reported. By reducing the alkalinity of the intestinal secretions these organisms tend to diminish the alkalinity of the blood, thereby aiding in the production of a general acidosis.
When such a
SMILEY O. THE FALLACY OF THE INDISCRIMINATE INTERNAL USE OF BULGARIAN BACILLUS: WITH SOME EVIDENT DANGERS. JAMA. 1915;LXV(12):1025–1026. doi:10.1001/jama.1915.02580120037013
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