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At the risk of seeming to offer a trivial suggestion, I wish to call attention to the advantages of inducing local anesthesia as a preliminary to intravenous injections, in which the larger bored needles, such as the 17 and 18 gage, can be used to advantage. The method as introduced by me into the dermatologic clinic of the University Hospital, Ann Arbor, Mich., in the administration of old salvarsan, consists in the injection of 1 or 2 minims of a 2 per cent. cocain solution with a very fine needle, immediately beside the distended vein at the point at which the large needle is to be entered. The injection should not raise a wheal, but should be given more into the subcutis than intradermally. Within a few seconds, anesthesia is sufficiently complete for the operator to make a careful and deliberate entry rather than a haphazard one, without a gesture
Stokes JH. LOCAL ANESTHESIA IN INTRAVENOUS INJECTIONS. JAMA. 1915;LXV(12):1027. doi:10.1001/jama.1915.25810120001015
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