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September 18, 1915


JAMA. 1915;LXV(12):1031-1032. doi:10.1001/jama.1915.02580120043018

The relation between mother and fetus has been studied in many directions, but little attention has been paid to the effect of diets on the fetus. Hoist and Frölich1 produced scurvy in guinea-pigs by keeping them on a diet of oats and water for from ten to twenty-eight days. With this diet, Ingier2 produced scurvy in pregnant guinea-pigs to determine what changes would occur in the fetus and whether light would be thrown on certain diseases in man, such as rickets and osteomalacia.

Ingier found that pregnant animals are sensitive to this restricted diet; of thirty-three, twelve had dead litters and many mothers died with dead fetuses in the uterus. Seventeen had their young during an early stage of the disease, and four in an advanced stage. Scorbutic changes were present in all of the fetuses, though in widely varying degrees. The young of mothers in which scurvy