The proof that general paralysis of the insane is an active syphilitic disease,1 together with the advent of intradural medication, has given a new hope in the treatment of these unfortunates.
The choice of technic in intradural treatment lies between the Swift and Ellis method,2 the Ravaut method,3 and the Byrnes method.4
The high cost of salvarsan and the scarcity of this product in our Western market have prevented us from using the Swift and Ellis method to any great extent. We were attracted by the Byrnes method because of its apparent freedom from danger and its low cost.
The patients here reported, twenty-three in number, have all been diagnosed clinically as having general paralysis, and the clinical diagnosis has been accepted as the basis for this work. The patients have not been selected as to the duration of disease, stage, or physical condition; but rather
IRELAND GO, WILSON CS. TREATMENT OF SYPHILIS OF THE BRAIN: A PRELIMINARY REPORT OF THE USE OF MERCURIC CHLORID INTRADURALLY. JAMA. 1915;LXV(13):1108–1110. doi:10.1001/jama.1915.02580130040014
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