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October 9, 1915


Author Affiliations


From the Research Laboratories of the Western Pennsylvania Hospital.

JAMA. 1915;LXV(15):1268-1271. doi:10.1001/jama.1915.02580150042012

In the course of the last two years the Abderhalden reaction has been brought to the attention of the medical profession so often that it is safe to assume that the fundamental facts discovered by Abderhalden are generally known. In short, Abderhalden, as does Ehrlich, assumes that normal cells of the body are able to assimilate only those substances present in the blood as its normal constituents. The changes brought about in the composition of the blood serum by introduction of foreign substances lead to disturbances in the processes of cellular nutrition and often to cellular death. The experimental study of the phenomena of assimilation of foreign material introduced directly into the blood stream revealed a number of facts pointing to the tendency of the cells to elaborate a special mechanism, by means of which the cells are able to protect themselves in a specific manner against the injurious effects