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October 23, 1915


Author Affiliations

Director of the Hygienic Laboratory of the California State Board of Health BERKELEY, CALIF.

JAMA. 1915;LXV(17):1413-1418. doi:10.1001/jama.1915.02580170001001

For over a year the California State Board of Health has been manufacturing at the hygienic laboratory the Gay-Claypole1 sensitized antityphoid vaccine and distributing it free to physicians. Data cards are sent with the vaccine and physicians are requested to describe reactions and complications and to report any cases of typhoid fever in those who have been vaccinated. When the data cards are not returned, a follow-up postal card is sent. Under this system reports of several cases of typhoid fever in vaccinated persons were received soon after the beginning of the distribution. The investigation here reported was undertaken to determine whether these failures were peculiar to the type of vaccine distributed by the state board of health and also to arrive at a more accurate idea of the value of antityphoid vaccination in the civil population.

The literature on antityphoid vaccination gives little information regarding its value under