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October 30, 1915


JAMA. 1915;LXV(18):1554-1555. doi:10.1001/jama.1915.02580180058021

The Abderhalden test for the presence of specific enzymes in the blood, which has frequently been referred to,1 has awakened interest not only in the possibilities of practical application which it represents but also in its relation to the underlying principles of immunity. Even a cursory review of the literature of the subject will indicate that Abderhalden's views have not gone unchallenged and his contentions have not remained without contradiction. The differences have ranged from the complete denial of the phenomena themselves to the mere expression of doubt as to the validity of their interpretation.

It will be recalled that according to Abderhalden the injection of foreign proteins of any kind into the blood leads to the prompt formation and appearance in the blood of enzymes which can digest proteins of the sort introduced, but not any other kinds. In the case of pregnancy, for example, it is postulated