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June 24, 1911


Author Affiliations


JAMA. 1911;LVI(25):1877-1878. doi:10.1001/jama.1911.02560250013007

I. PREPARATION FOR INTRAVENOUS ADMINISTRATION  The cells of every living organism are adjusted to a certain osmotic tension and any variation of this tension in the fluids surrounding the cell injures it; therefore, the concentration of solutions of salvarsan injected intravenously is a matter of some importance. The practice seems to be to dissolve the salt in a variable amount of water and then to neutralize with sodium hydroxid, the exact osmotic tension of the resulting solution being a neglected factor. This is then brought up to a volume of 200 or 300 c.c. by adding, in some cases, physiologic salt solution, and in others distilled water. The statement is frequently made that 0.6 gm. of salvarsan neutralized and dissolved in 250 c.c. of distilled water approaches closely the osmotic tension of the fluids of the body. The fallacy of this can easily be shown.We ordinarily accept a solution