With the pneumococcus, as with most bacteria, the bulk of immunologic studies has been made with animals possessing a relatively high susceptibility to that organism. On the other hand, the general studies concerning the formation of antibodies have shown that specific antibody production is not directly dependent on any pathogenic value of the substance injected: Thus the precipitins to innocuous proteins; the agglutinins and hemolysins, to red blood-corpuscles; and, indeed, certain antitoxins themselves, namely, those resulting from toxoid injections, are all produced by the employment of antigens having no disease-producing power.
Starting from this point, I have tested the possibility of obtaining antibodies to pneumococci and their products, by the systematic inoculation of a relatively insusceptible animal with extreme doses of virulent pneumococci. The animal selected for this purpose was the common barn-yard fowl, birds in general being insusceptible to pneumococcus infection.
The pneumococci employed in the following experiments were
KYES P. THE PRODUCTION OF ANTIBODIES TO PNEUMOCOCCI IN AN INSUSCEPTIBLE HOST. JAMA. 1911;LVI(25):1878–1881. doi:10.1001/jama.1911.02560250014008
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