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In searching for the presence in the urine of abnormal products of elimination in cases of malignant disease, we observed that methylene-blue was decolorized by the urine taken from these patients. Repeated examinations and more extensive investigations demonstrated that urines in cases of rheumatism, nephritis, meningitis, etc., were also sometimes decolorized, but generally to a minor and variable degree. In most instances the latter conditions could be easily differentiated and eliminated, so that it appears as if this reaction may have considerable value in the diagnosis of malignant disease. It is for this reason deemed justifiable, at this early stage, to make this brief preliminary report, so that other observers may investigate the value of this test by experimenting on a larger number of cases.
So far, this test has been positive in every well-established case of malignant disease. Many of these cases have been corroborated by operations and post-mortem
FUHS J, LINTZ W. THE DIAGNOSTIC SIGNIFICANCE OF THE URINARY METHYLENE-BLUE REACTION WITH SPECIAL REFERENCE TO MALIGNANCY: PRELIMINARY REPORT. JAMA. 1911;LVI(25):1882. doi:10.1001/jama.1911.02560250018010
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