The scope of this paper has been intentionally limited to a consideration of the value of radium in treating the malignant epithelial new growths of the vagina and cervix uteri. Equally interesting technical problems and clinical phenomena are met when radium is used in treating other kinds of malignant tumors, for example, the sarcomas and carcinomas, and tumors in other organs, as the bladder, breast, tongue, etc. The technic, the indications for treatment and results obtained vary with the type of tumor and its location so greatly that each demands separate consideration. It is especially difficult to have to exclude the adenocarcinoma of the fundus uteri, as it is quite radiosensitive and as we have of it the most excellent material, both clinical and anatomic. The problems connected with its surgical as well as radium treatment, however, differ widely from those of the cervical—uterine and vaginal — cancers.
HOWARD A. KELLY, CURTIS F. BURNAM. RADIUM IN THE TREATMENT OF CARCINOMAS OF THE CERVIX UTERI AND VAGINA. JAMA. 1915;LXV(22):1874–1878. doi:10.1001/jama.1915.02580220014007