Tuberculin is a valuable remedy in pulmonary tuberculosis when the lesion is limited in extent, and when the disease is pursuing a slow course with neither much febrile manifestation nor much general systemic disturbance. In afebrile advanced pulmonary tuberculosis, with fair appetite and digestion and little or no systemic disturbance, it may also be valuable. It must be used with caution in young tuberculous patients with actively incipient lesions, since frequently the injection of very minute doses produces a most vigorous reaction, whrereas large doses in old tuberculous subjects do not produce any reaction at all; it should always be borne in mind that in recent infection and in the exacerbations which occasionally follow an old lesion, the reaction may he severe even when infinitesimal doses have been applied.
The indications for the use of tuberculin are usually in those early cases which have long been under observation and in
RITTER J. THE THERAPEUTIC APPLICATION OF TUBERCULIN IN THE TREATMENT OF AMBULATORY PULMONARY TUBERCULOSIS: ITS INDICATIONS AND CONTRA-INDICATIONS. JAMA. 1911;LVII(2):93–95. doi:10.1001/jama.1911.04260070097002
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