An important step in the development of our knowledge of the phenomena of immunization was the demonstration that the treatment by injection of an animal with a foreign protein, bacterial or otherwise, leads to profound changes in the body which may endanger as well as protect the life of the animal when this protein is reinjected. These changes are characterized by the formation of antibodies which, while they increase the resistance of the animal against subsequent inoculations of toxins and microbes, certainly seem to render the body highly susceptible to poisoning in the instance of innocuous proteins. This apparent hypersusceptibility, which we speak of as allergy or anaphylaxis, may be so marked that a second injection of the foreign protein results in severe or even fatal injury to the animal. The clinical and pathologic picture of the allergic reaction suggests that the injury to the cells is due to a
RECENT ADVANCES IN KNOWLEDGE OF ALLERGIC PHENOMENA. JAMA. 1915;LXV(26):2240–2241. doi:10.1001/jama.1915.02580260034017
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