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September 2, 1911

EFFECT OF TUBERCLE PRODUCTS ON EPITHELIUM

Author Affiliations

PHILADELPHIA

Commonwealth of Pennsylvania Department of Health Laboratories.

JAMA. 1911;LVII(10):800-801. doi:10.1001/jama.1911.04260090022011

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Abstract

That tubercle bacilli or their products have a stimulating effect on epithelial structures we have convinced ourselves. This was quite clearly shown in our work during 1909 and the experiments early in 1910 abundantly corroborated it. We could only be sure of the effects on the epithelium in bile-ducts and bronchi, however, while in mamma and skin epithelium the appearances were far from regular. The work has therefore turned toward establishing conditions which could produce definite continuing results. The results in regard to the organs used are given here.

I. RABBIT EAR  For the purpose of stimulating the growth of epithelium on the ear, two methods were used, one of injecting the material as closely beneath the epidermis as possible, another by rubbing wax derived from tubercle bacilli into an abraded surface on the ear skin. The results seen under the microscope are detailed below.

Ear of Rabbit 57.  —Thirteen

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