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Article
September 2, 1911

A THEORY FOR THE PATHOLOGIC PHYSIOLOGY INVOLVED IN DISEASE OF THE THYROID GLAND AND ITS THERAPEUTIC APPLICATION: EXPERIMENTAL STUDIES

JAMA. 1911;LVII(10):801-807. doi:10.1001/jama.1911.04260090023012
Abstract

A SUMMARY OF WHAT IS KNOWN ABOUT THE PHYSIOLOGY OF THE THYROID  It is now accepted as reasonably certain that the thyroid discharges into the circulation a secretion which is of importance for many organs and tissues; that this exerts its effects directly on some and indirectly on others, possibly through the nervous system; that the formation of this secretion is the only function of the thyroid and that it has no other constructive or destructive attributes; that the physiologic activity of the thyroid secretion is dependent on an iodized protein or proteins and that it seems roughly proportionate in activity to its iodin content; that this secretion seems not to be destroyed during its utilization but to be reabsorbed by the thyroid with little or no loss; this fact in itself suggests the possibility of auto-activation of the gland.It also seems to have been demonstrated that iodin starvation

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