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Article
September 2, 1911

THE PHENOLSULPHONEPHTHALEIN TEST FOR ESTIMATING RENAL FUNCTION

Author Affiliations

BALTIMORE

From the Genito-Urinary and Medical Clinics of the Johns Hopkins Hospital and the Pharmacological Laboratory of the Johns Hopkins University. Read before the New York Academy of Medicine, May 4, 1911.

JAMA. 1911;LVII(10):811-816. doi:10.1001/jama.1911.04260090033014
Abstract

INTRODUCTION  In July, 1910,1 we presented our original communication on the results obtained on our experimental and clinical studies of the functional activity of the kidneys by means of phenolsulphonephthalein. Some additional data were presented in subsequent papers.2 The present communication is a summary of our experience with the test during the past two years,3 and deals particularly with its value in relation to nephritis.Phenolsulphonephthalein,4 which was first prepared by Remsen, is a bright red crystalline powder somewhat soluble in water and alcohol, but readily soluble in the presence of alkalies. The drug, as determined by Abel and Rowntree, is non-toxic, excreted with extraordinary rapidity, and appearing in the urine normally within a few minutes of injection. In alkaline solution a brilliant red color is produced, which is ideally adapted for quantitative colorimetric estimations.

TECHNIC  Twenty minutes to half an hour before administering the test,

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