That the intelligent employment of tuberculin in the treatment of tuberculosis is attended with excellent results, is now almost universally admitted. To be sure, there are still some who are unconvinced. Absolute unanimity of opinion, however, has rarely been attained in medicine, and we are not expecting it in this instance.
Tuberculin is by no means an easy remedy to administer. It requires much careful study and close observation to be able to use it to best advantage. The proper administration requires the giving of the right dose at the right time. To administer the right dose at the right time requires judgment born of experience; for it cannot be determined by rule. Tuberculin treatment is not what it is often supposed to be: merely the introduction of a certain number of drops of a certain dilution of tuberculin into the body tissues by means of a hypodermic syringe, and
FRANCIS M. POTTENGER. SOME DIFFICULTIES ENCOUNTERED IN THE THERAPEUTIC USE OF TUBERCULIN. JAMA. 1911;LVII(12):940–945. doi:10.1001/jama.1911.04260090162002