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Thyroid therapeutics is an acquisition of the last six years, and one that better than perhaps any other illustrates the close relations between physiologic research and the rational treatment of disease. It is not very long since that the thyroid, like other ductless glands, was a physiologic puzzle, and the theories as to its utility in the organism varied from that of its being a merely esthetic appendage to round off the contour of the throat to the attributing to it an important action in mechanically regulating, as a diverticulum, the blood supply of the brain. The recognition of the connection of the cretinoid condition described by Gull with atrophy of this gland by Ord in 1877, and the subsequent experimental studies of Schiff and his assistants and of Horsley in England, and others, led directly to the theory of the chemico-vital function of the thyroid and to the suggestion
THYROID THERAPEUTICS. JAMA. 1896;XXVII(9):498–499. doi:10.1001/jama.1896.02430870046007
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