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October 7, 1911


JAMA. 1911;LVII(15):1184-1187. doi:10.1001/jama.1911.04260100010003

In the mid-course of chronic interstitial neph with the secreting structures of the kidneys greatly reduced by degenerative and atrophic processes, more or less marked renal insufficiency is the rule. With the high-pressure circulatory balance well maintained, the urinary water flows in full or increased volume, the insufficiency being confined to an inadequate excretion of certain waste and superfluous determinable and occult substances which are deleterious to the human body, and which are ordinarily efficiently removed by healthy kidneys. It is probable that the most toxic and important of these are, as yet, demonstrable only by their effects. In the future, when methods shall have been perfected whereby these may be differentiated and measured, our problem will be susceptible of ready and accurate solution. For the present, and for our practical purposes, we are compelled to rely on the amount of urea, eldorids, phosphates and sulphates contained in the daily

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