For several years iron preparations have been used hypodermatically in the treatment of secondary, and arsenic in the treatment of pernicious, anemia. In 1908 Peters1 reported favorable results after two years' use of iron citrate hypodermatically in the treatment of secondary anemia of tuberculosis, employing a number of formulas of different combinations.
Later Morse2 reported satisfactory results even in severe cases with citrate of iron subcutaneously in the treatment of anemia in infancy. He found the rise in the percentage of hemoglobin was more rapid than that in the number of red blood-corpuscles.
Dickinson,3 on hypodermic treatment of anemia, says where medicinal preparations fail, when the anemia cannot be relieved, and where digestion is markedly embarrassed by medication, the hypodermic use of iron must be resorted to. Each of these authors speaks of the pain caused at the site of injection.
Of the beneficial effects of arsenic
BARLOW WJ, CUNNINGHAM RL. EFFECTS OF HYPODERMIC INJECTION ON THE SECONDARY ANEMIA OF CHRONIC PULMONARY TUBERCULOSIS. JAMA. 1911;LVII(18):1435–1441. doi:10.1001/jama.1911.04260100261009
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