For many years the idea has existed among various observers that there is a relation between symmetrical gangrene and malaria. This relation was hardly appreciated by Raynaud1 in his thesis, although several of his cases were malarious subjects. In Case 6, which was reported in 1837 by Marchand, the patient was a woman who had had an outbreak of the gangrene six weeks after an attack of tertian malaria. Likewise the patient in Case 7 had had a three months' attack of tertian malaria preceding the gangrene. The patients in Cases 23 and 25 had had obscure fever. In the New Researches the patient in Case 1 was a malarious subject, and in Case 5 the patient had had attacks of fever. In 1869 Rey reported a case in which the patient had been affected with gangrene after attacks of intermittent fever in Senegal and later in France. In 1870
WOOD EJ. A MIXED INFECTION WITH TERTIAN AND QUARTAN MALARIA OCCURRING IN A PATIENT WITH SYMMETRICAL GANGRENE.. JAMA. 1907;XLIX(23):1891–1895. doi:10.1001/jama.1907.25320230007001b
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