In several former papers1 we described a simple method which permitted us with great certainty to produce a combination of hypertrophic and myocarditic changes within a relatively short time in the heart of the rabbit. At the same time we suggested an explanation of these phenomena without, however, going into any detailed discussion regarding the basis for our theoretical conceptions. Inasmuch as it appears to us that the principle underlying our explanation of the phenomena observed in the rabbit may, perhaps, be extended to the pathology of the heart in man, we believe that a somewhat more detailed discussion of our theory might be of advantage.
The method employed by us in the production of hypertrophic and myocarditic changes in the heart of rabbits was, briefly, as follows: We injected into the earvein of a rabbit a single small dose of epinephrin (0.2 c.c.) preceded by spartein sulphate or
LOEB L, FLEISHER MS. THE PATHOGENESIS OF CARDIAC HYPERTROPHY AND MYOCARDITIS. JAMA. 1911;LVII(19):1529–1531. doi:10.1001/jama.1911.04260110029011
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